Abstract: The Dushan antimony ore concentration area in Guizhou Province is one of the most important Devonian antimony metallogenic regions. It has superior ore-forming geological conditions and abundant mineral resource. In the Dushan antimony ore concentration area, 1 large, 2 middle, 5 small and 13 antimony ore spots have successively been found. Based on antimony metallogenic conditions, geochemical anomaly, geophysical anomaly and remote sensing image interpretation, the authors summarized exploration indicators of strata and lithology, tectonic, alteration, geochemistry, remote sensing and geophysics. In the prospecting toward the deep subsurface of the the Banpo antimony deposit in Dushan County, the authors used exploration indicators of metallogenic fault, closed high resistance body of geophysical anomaly from CSAMT geophysical anomaly, drilled engineering validation holes, found a new concealed rich antimony orebody, and achieved a deep concealed ore prospecting breakthrough. In the comprehensive study of various kinds of abnormal information and on the basis of exploration marks, the authors delineated and optimized the three prospecting target area of Banpo periphery, Nongjiang-Guixiu-Jiabai-Beida and Weizhai areas. In the course of ore comprehensive prospecting in the future, it is expected to achieve new prospecting breakthrough through optimization and integration of detection technologies and new evaluation of the old mine.