Abstract: The database of 1∶50 000 mineral geological map of Hongshi Map-sheet (K46E009008) in Kalatage Copper (-Zinc) Deposit, Hami, Xinjiang (also referred to as the Database) was developed through field geology-specific mapping using the digital mapping system in accordance with the Technical Requirements of Solid Mineral Geological Survey (1∶50 000) (DD2019-02) and other standards and requirements in the geological industry. Meanwhile, the results of previous 1∶200 000 and 1∶50 000 regional geological surveys were fully utilized, and indoor and outdoor mapping/compilation was also carried out during database building. In this database, the suites of the Daliugou Formation of Middle-Upper Ordovician Huangcaopo Group as well as Lower Silurian Hongliuxia and Kalatage formations were reclassified. Moreover, the formation time of intrusive rocks in the map-sheet area was determined as Silurian, Devonian, and Permian, and the evolutionary sequence of magmatic rocks was established. There are eight large, medium and small mineral deposits and ore occurrences in the map-sheet area, the metallogenic epoch of which is concentrated in the Silurian and Carboniferous. The ore-hosted wall rocks are pyroclastic and subvolcanic rocks. The dominant mineral resources in this area are copper, zinc and gold, and their deposit types are mainly VMS type and subvolcanic hydrothermal vein type, which are distributed in the southeastern zone of the map-sheet area. In addition to metallic minerals, there are bentonite deposits with good prospecting potential. With a data size of about 15.1 MB, this database contains the data of five stratigraphic units and three stages of magmatic rocks. These data fully reflect the demonstration results of 1∶50 000 mineral geological survey of this map-sheet and provide references for the research and exploration of mineral resources in the survey area.